lynnsa10 replied the topic: Lexaria Corp CSE:LXX OTC:LXRP
Great news first licensing deal in California, the largest Pot market
Kelowna, British Columbia / TheNewswire / April 25, 2018 - Lexaria Bioscience Corp. (OTCQX: LXRP) (CSE: LXX) (the "Company" or "Lexaria") a drug delivery platform innovator, announces it has entered a definitive technology licensing agreement (the "Agreement") with GP Holdings LLC. ("GP") whereby Lexaria is providing its patented DehydraTEC H(tm) technology to empower next-generation performance in high absorption, fast acting cannabis infused beverages to be developed and sold in California.
GP is establishing its operation as the leading THC beverage contract manufacturer in the state of California and expects the commencement of operations from its new state-of-the-art bottling facility within the next two quarters. Lexaria and GP have been collaborating for months to develop the highest performing cannabis beverages available anywhere, with nearly zero unwanted cannabis odor or flavor, and complete clarity and transparency of even sparkling beverages. More info about GP can be found at
GP has acquired 5-year semi-exclusive rights to use Lexaria's DehydraTEC H(tm) technology for beverage applications within California for an undisclosed sum and a royalty on revenue generated on products sold utilizing DehydraTEC H(tm) . In addition, GP also intends to develop topical skin products using the technology and has also acquired matching rights for this application.
The California cannabis-bev erage market is expected to be one of the largest edible product segments, and this agreement continues Lexaria's progress of building an international ecosystem empowering licensed producers of all sizes with the ability to create best-of-class sector leaders. Under the terms of the semi-exclusive Agreement, Lexaria can offer other licensee partners the option of utilizing GP's formulation and manufacturing expertise to produce cannabis infused, DehydraTEC H(tm) -powered beverages and topicals throughout the state of California.
"The use of DehydraTEC H(tm) triggers a race to the top in the California THC beverage and topicals market through this 5-year license agreement," said Chief Executive Officer Chris Bunka. "This is another long-term strategic relationship that will give consumers the faster acting and highly potent products they deserve, and class leading flavor profiles for the beverage segment in particular."
Next Generation Nicotine Delivery USA brings together strategic leaders from across the new nicotine products category together with solution providers for 2 days of insight, discussion and debate.
• Lexaria Bioscience has two prominent speaking appointments to present their latest ingestible nicotine absorption breakthrough: Link
• To an audience of big tobacco players and regulatory representatives, Lexaria is presenting the only novel and unique approach to new nicotine products. Other cohorts are discussing enhancements to vaping devices, e-cigarettes and heat-not-burn products.
Lexaria is sometimes thought of as a cannabis company and I frequently remind people I speak with that we are so much more than that. In fact our DehydraTECHTM technology has applications that dwarf the cannabis industry.
A global shift in the world’s largest consumer market has already begun… at US$980 BILLION per annum, the global tobacco market is nearly double the combined 2017 revenues of Apple, Amazon, Microsoft and Alphabet and roughly 100 times larger than last year’s legal global cannabis industry.
1.1 BILLION users (1 in 5 adults) smoke tobacco for the nicotine – a highly addictive substance. But, addictiveness alone doesn't necessarily make a product dangerous. Nicotine is highly addictive, but in the quantities found in cigarettes, not itself a major cause of disease. Rather, it is the burning of tobacco and other substances inhaled through smoking that cause cancer, heart disease and bronchitis. It’s time to separate the dependence from the harm... and the FDA agrees.
• FDA Commissioner Dr. Scott Gottlieb: "The overwhelming amount of the death and disease attributable to tobacco is caused by addiction to cigarettes. Addiction causes long-term sustained use. But it’s exposure to the harmful chemicals [from combustion] that causes disease.”
On July 28, 2017, the FDA announced a 2-pronged strategy: 1) reduce nicotine in conventional cigarettes to non-addictive levels; and 2) encourage and assist a new class of FDA-reviewed products that deliver nicotine without the toxic by-products of burning tobacco.
• FDA's Plan for Tobacco and Nicotine Regulation: Link
Big Tobacco Gets Smoked
Last week on April 19th, Philip Morris announced disappointing sales growth in Japan for their heat-not-burn products. The stock tanked 16%, wiping out US$20 BILLION in market value in one trading session. Let that number sink in for a moment. One company – a single day. More market cap lost in one day that ALL the combined sales of ALL the world’s combined legal cannabis companies in the past year. How much pain will the tobacco industry endure before it embraces radical new delivery technology?
• Are Cigarettes Finally Dead? Link
• Philip Morris has worst day in a decade as iQOS growth in Japan 'plateaus' Link
Are there any solutions? The world is desperate for a novel alternative nicotine product that satisfies not only the physical nicotine craving, but also the behavioural, social and emotional aspects that conventional cigarette users desire.
• An ingestible nicotine food/beverage product is an eloquent solution – most smokers already consume a beverage or food with smoking when possible - but does not currently exist due to historic GI (gastro-intestinal) delivery problems.
Lexaria Bioscience Corp. has already made significant progress on an ingestible nicotine formulation and is investigating parallel paths for both a nicotine replacement therapy (NRT) and an alternative nicotine product. These are separate markets with individualized needs.
Lexaria’s Breakthrough Test Results
We already demonstrated in live rats that DehydraTECHTM can get nicotine from edibles into the bloodstream in 15 minutes (in fact we know we can do it in less) compared to nearly 3 HOURS without our tech. This is an incredible step forward towards Lexaria’s goal of creating an entirely new product segment: nicotine edibles.
We’re already planning additional tests and formulations and will work to optimize the technology for even faster delivery. As we’ve demonstrated time and again, building a database of test results gives us a seat at the industry table and, we hope, leads eventually to market dominance.
• April 17, 2018: Significant Breakthrough in Nicotine Delivery Technology Link
• March 14, 2018: Positive Nicotine Tolerance Observed Link
• December 13, 2017: Nicotine Patent Awarded Link
Lexaria remains committed to all the market sectors its technologies can empower including cannabis, nicotine, and more....Stay Tuned!
For all the latest news and updates while on the go just text "lexaria" to 76000.
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alexgreat replied the topic: Lexaria Corp CSE:LXX OTC:LXRP
KELOWNA, BC / ACCESSWIRE / April 23, 2018 / Lexaria Bioscience Corp. (OTCQX: LXRP) (CSE: LXX) (the ''Company'' or ''Lexaria''), a drug delivery platform innovator, is pleased to announce that it has commenced a clinical study in Europe to evaluate the cardiovascular and cognitive health effects of Lexaria's high absorption TurboCBD™ capsules.
The pharmacokinetic and pharmacodynamic data generated by this study will provide objective human performance findings that will assist in the development of the Company's next-generation cannabinoid product formulations and be of significant benefit to the Company and its partners.
The study employs a double-blind and placebo-controlled cross-over design measuring TurboCBD™ effects both after a single 45mg dose and, on a separate day, after a single 90mg dose in 12 healthy male volunteers. The study hypothesises that, following TurboCBD™ supplementation, circulating CBD and nitric oxide will increase in most participants; that glucose and blood pressure will remain stable; and that vascular function, and cognitive performance will improve. The same DehydraTECHTM technology is being used to deliver CBD in this human study, as was used by the Company in its recent rodent-based nicotine absorption study, illustrating the wide applicability of the Company's patented drug delivery platform.
This advanced study will utilize the latest clinical evaluation techniques to provide pharma-level pharmacokinetic and pharmacodynamic performance data of TurboCBD™, including blood sampling, physiological measures, cognitive function testing and cardiovascular function testing. Outcome measurements will include circulating CBD and nitric oxide markers, plasma glucose, plasma insulin, blood pressure, heart rate, respiration, peripheral and brain blood flow and a battery of neuropsychological performance tests.
This study was originally intended to be conducted at the University of British Columbia but policy change has resulted in a move to a medical university in Europe, where it is presently being conducted. Study results are expected within 90 days. Depending on results, a second phase clinical study in elderly is already designed and has received necessary regulatory approvals and could commence later in 2018.
Breakthrough Nicotine Absorption Results To Be Presented Tomorrow in Atlanta, GA.
Separately, Lexaria announces that it is presenting the results of its recent breakthrough nicotine absorption study at the Next Generation Nicotine Delivery 2018 USA conference April 24th & 25th 2018, in Atlanta, USA. The Company has two prominent speaking appointments to present their latest ingestible nicotine absorption breakthrough: Link
To an audience of big tobacco players and regulatory representative, Lexaria is presenting the only truly novel and unique approach to new nicotine product delivery in the industry today.
DearJohn replied the topic: Lexaria Corp CSE:LXX OTC:LXRP
PMI stock is down 16% today, wiping out $20B of market value (which is about the size the entire cannabis market combined). The race for alternate nicotone delivery methods is just getting started.
Lexaria announced successful lab results on Monday, showing alternate nicotine delivery through GI tract in lab rats. Timing is excellent for Lexaria's presentation at the nicotine industry conference next week in Atlanta - with a focus on alternate delivery.
alexgreat replied the topic: Lexaria Corp CSE:LXX OTC:LXRP
Great news with LXX on nicotine tests
Lexaria delivers nicotine to bloodstream in 15 min
2018-04-17 08:19 ET - News Release
Mr. Alex Blanchard reports
LEXARIA ACHIEVES SIGNIFICANT BREAKTHROUGH IN ALTERNATIVE NICOTINE DELIVERY TECHNOLOGY
Lexaria Bioscience Corp. has provided positive top-line results upon completion of its first ingestible nicotine in vivo (animal) absorption study. Lexaria is pursuing the use of its patented DehydraTECHTM technology as a possible new nicotine delivery method, an edible dose absorbed through the gastrointestinal tract, with potential both as a nicotine replacement therapy as well as an alternative product format for regular tobacco users.
DehydraTECHTM delivered the following major nicotine absorption performance improvements:
1,160% faster delivery of equivalent peak quantities of nicotine to the bloodstream than achieved with controls (within 15 min vs. 2.9 hours);
148% gain in the quantity of peak nicotine delivery to the bloodstream relative to controls;
560% higher brain levels of nicotine where nicotine effects are focused, compared to controls;
Lower urine levels of nicotine excreted than controls, for enhanced nicotine activity and bioavailability over the course of the study;
Lower quantities of key liver metabolites in the bloodstream than controls as hypothesized, suggesting bypass of first pass liver metabolism.
Study Design Parameters:
The study was designed to principally assess the relative ingestible nicotine absorption performance of DehydraTECHTM-powered formulations compared to concentration-matched control formulations that lacked any form of delivery enabling technology in rats. Nicotine was administered in a nicotine polacrilex derivative format as is widely commercialized today in nicotine replacement therapy products such as chewing gums. Twelve male rats were divided into four groups of three, such that DehydraTECHTM and control formulations were each tested at a 1 mg/Kg and 10 mg/Kg dosage level. Formulations were administered orally and all rats were cannulated for blood collection at multiple intervals over an 8-hour duration post-dosing with the first data collection at the 15-minute mark. Urine and feces were also collected for up to a 24-hour duration post-dosing, and essential organ tissue samples were also collected for examination after the study. All samples were subjected to analytical testing in order to quantify the levels of nicotine therein, as well as the levels of three major liver metabolites thereof, hydroxycotinine, nicotine N'-oxide, and cotinine, in order to assess the relative metabolite levels absorbed by the different formulations. Lexaria's hypothesis was tested to prove that its DehydraTECHTM technology would influence more rapid and complete intestinal bioabsorption of nicotine lymphatically with less metabolic degradation by the liver. All animals were also assessed for general tolerability of the administered formulations. The study was conducted at the same independent laboratory in Philadelphia where the Company completed its initial cannabidiol absorption study in 2015.
Results & Observations:
The Lexaria formulations generally achieved faster absorption, higher peak absorption and higher overall quantities of nicotine, on average, in the blood than the concentration-matched control formulations at both the 1mg and 10 mg/Kg doses tested. Furthermore, as previously reported, there were no obvious signs of gastrointestinal distress such as vomiting or diarrhea indicating that the animals appeared to tolerate the treatment well.
Nicotine blood levels were evaluated multiple times over a period of 8 hours after dosing. In the 10mg/Kg dosing arm, the control formulation required nearly 3 hours to reach similar levels of blood absorption that the Lexaria formulation reached in only 15 minutes. Furthermore, the Lexaria formulation went on thereafter to demonstrate peak plasma levels that were 148% of those achieved by the control formulation. If replicated in human studies, these findings are suggestive that Lexaria's technology could prove more effective in elevating blood nicotine levels through edible formats much more quickly and substantially than previously theorized, potentially making ingestible nicotine preparations a viable alternative to today's available product formats while also leading to a more rapid nicotine craving satiation.
Analysis of the liver metabolites revealed, as expected, that overall levels in the blood of two of the three metabolites studied were higher in the control group than in the Lexaria formulation group at the 10 mg/Kg dose. This result was especially pronounced in the 45-minute to 2-hour time interval post-dosing which is consistent with the expected timing of the release of metabolites in higher quantity into the bloodstream by the liver following normal physiological processing of ingested nicotine with the control preparation, compared to the DehydraTECHTM technology that is believed to elude first pass liver metabolism. The Lexaria formulation also demonstrated lower quantities of nicotine in the rat urine at both doses, which is consistent with the fact that the levels of nicotine in the rat blood remained higher over the duration of the study with the Lexaria formulation than with the control. The study also revealed that the Lexaria formulation at the 10 mg/Kg level achieved up to 5.6-times as much nicotine upon analysis of the rat brain tissue that was recovered with the matching control formulation. These findings together perhaps suggest prolongation of nicotine effectiveness with the Lexaria formulation which may also be beneficial in humans to control cravings over an extended time-period from a single edible nicotine dose.
"We are very pleased with these topline study findings demonstrating excellent tolerability and substantially faster, more potent and bioavailable absorption of nicotine in an ingestible format with our DehydraTECHTM technology than controls," said John Docherty, President. "This data supports further investigation of the many possible benefits of our DehydraTECHTM technology for nicotine delivery with potential both as a nicotine replacement therapy as well as an alternative product format for regular tobacco users over today's inhaled options."
Further analysis of the existing data is required, and additional datasets from the study are still being processed and have not yet been received by Lexaria. New studies are being planned to pursue investigatory leads produced.
Lexaria's patented DehydraTECH™ technology is focused on improved delivery methodologies of many commonly used active pharmaceutical ingredient ("API") substances. As such, it provides an additional layer of effectiveness that is designed to harmonize with the intellectual property of third parties. Both patented and generic API substances can utilize Lexaria's patented technology. Lexaria's long-term strategy is to partner with the world's leading firms as they deliver best-of-class products to their existing large consumer groups.
GoldnBoy replied the topic: Lexaria Corp CSE:LXX OTC:LXRP
A positive out of Trump
The Globe and Mail report in its Saturday edition that Colorado Republican Senator Cory Gardner says President Donald Trump's decision to let states decide how to regulate marijuana is a major boost for the legal-pot industry. A Bloomberg dispatch to The Globe reports that Mr. Gardner says as a result of Mr. Trump's assurances, he will end a blockade of Justice Department nominees. Mr. Gardner held up the nominees after Attorney General Jeff Sessions rescinded an earlier Justice Department memo that shielded marijuana operations in states such as Colorado from enforcement of the federal ban on the drug. Mr. Gardiner says: "Since the campaign, President Trump has consistently supported states' rights to decide for themselves how best to approach marijuana. President Trump has assured me that he will support a federalism-based legislative solution to fix this states' rights issue once and for all." White House press secretary Sarah Huckabee Sanders said Mr. Gardner's statement is "accurate." Ms. Huckabee Sanders said Friday, "The President is a firm believer" in states' rights. Marijuana stocks surged on the news.
Gambler replied the topic: Lexaria Corp CSE:LXX OTC:LXRP
GB, I agree
The Globe and Mail reports in its Thursday edition that analyst recommendations on weed stocks have been "laughably inaccurate." The Globe's David Berman writes that he looked at 26 analyst recommendations by five brokerages for six marijuana stocks, which is a wide sample of the overall coverage of the marijuana sector. He graded the results based on whether the calls made money, lost money, missed rallies or avoided declines. Nearly half of the calls (12 of 26) received letter grades of C or lower, meaning that the call either lost money or missed rallies. This dismal performance implies that analyst recommendations are not providing much assistance. Canada's pot sector is striving for acceptance by sophisticated long-term investors, and coverage by financial analysts is a step toward respectability. The weed sector has attracted analysis by Cormark Securities, Beacon Securities, Echelon Wealth Partners, GMP Securities and Canaccord Genuity. This week, BMO Nesbitt Burns became the first bank-owned brokerage to begin covering the marijuana sector. Mr. Berman says given the overall inaccuracy of recommendations, it is nearly impossible for investors to know which opinion to follow, on which stock, and when.
They should be listening to Struthers and would have made a killing on LXX and CBW, his recent call for LXX to $1.05 was very good. Hope it does not go lower
GoldnBoy replied the topic: Lexaria Corp CSE:LXX OTC:LXRP
The LCBO said that the first Ontario Cannabis Store locations will be in Guelph, Kingston, Toronto and Thunder Bay. Just 4 locations, bet there will be massive line ups. I would think many will continue through current medical channels.
RonS replied the topic: Lexaria Corp CSE:LXX OTC:LXRP
TORONTO, April 9, 2018
HMMJ remains the world's largest Marijuana ETF
TORONTO, April 9, 2018 /CNW/ - Horizons ETFs Management (Canada) Inc. ("Horizons ETFs") is proud to announce that the Horizons Marijuana Life Sciences Index ETF ("HMMJ") has reached its one-year anniversary. HMMJ generated a one-year return for the period ending April 4, 2018, of 58.6% – making it the best-performing Canadian-listed ETF during this timeframe.
Since its inception on April 4, 2017, HMMJ – the world's first and largest Marijuana ETF – has brought in significant assets under management ("AUM"). Its AUM peaked at approximately $863 million on January 23, 2018 before market pull-backs. Its AUM now stands at over $622 million (as at April 6, 2018).
Gambler replied the topic: Lexaria Corp CSE:LXX OTC:LXRP
The Globe and Mail reports in its Monday edition that TD Bank is limiting the ways in which its advisers discuss the industry with clients, banning staff from recommending almost all marijuana firms and exchange-traded funds (ETFs). The Globe's Clare O'Hara and Christina Pellegrini write that TD is also prohibiting portfolio managers from pro-actively adding most cannabis shares to client investment accounts -- unless clients specifically instruct their adviser to do so. As a result, TD Wealth Private Investment Advice has put dozens of pot stocks and the four cannabis ETFs onto its non-approved list of securities, leaving advisers with only three Canadian marijuana stocks to suggest. As of Friday, TD advisers were approved to recommend the country's largest publicly traded producer of the drug, Canopy Growth, and two smaller, growers called Emerald Health Therapeutics and Emblem. The restrictions put on advisers who work at PIA appear to be driven out of concern of the legal risks the bank could face in the United States, where cannabis is legal in some states but illegal under federal law. The TD policy includes companies with no U.S. operations; it is not clear why those companies are included.